Journal

Chapter 1: Life is short, let's make it longer

This is April 15th 2020.

I am sick. I cannot breathe. There is blood in my stool.

Will I live tomorrow?

What will happen of my body? Was my life fulfilled? NO!

My goal is to live as long as possible in the healthiest way.

Shrodinger said in his book "What is life?" in 1946: "Life is an aperiodic cristal", before we discovered DNA with Xray cristallography in 1952. We are but a mass of matter that organized itself. "Organ"-ized!.

Life is matter that creates order at the expense of its environment creating entropy. Less entropy in the body and more entropy outside which is creating homeostasis: A balance within the body.

This means that life itself is but chemical reactions. The mind and the body are one.

We are angrier with more testosterone, happier with dopamine and serotonine, sleepier with melatonine etc.

This means we can compute life. If we manage to compute biological reactions, we can compute life itself. We can create life, modify life, enhance it but also deleting it. If a version of life is physically possible, then we will be able to make it. GMO are just a start. Crispr cas9 is a baby step

The main hindrances are two fold: computational, practical.

First computational, because just computing exact interactions between a few dozen atoms using the Shrodinger equation is enormous.

Second practical, because even if we manage to compute all the interactions possible we need to make this possible in practice with tools that can actually measure (ex: PET scan), create (using egg embryos) and modify life (Crispr cas 9).

So what can I do personnaly to help with this endeavour? I can bring my computation power to the cause (brain and graphic card). My brain to make tools already available through Command Line Interfaces to graphic interface, and make new algorithms that simulate matter in a quantum scale. My graphic card a mere 4090 would help me test these algorithms.

Before I code any complicated algorithm, I want to bring together all the information available. For example, deepmind managed to simulate matter in a quantum scale, I want to understand what they did, make a brief memo about it and then tools to help health professionals.

In order to help and organize this massive problem. I am dividing it into 7 different categories. Fundamental (mostly about mathematics), Atomic and quantum (mostly about quantum physics and computing), Molecular (mostly about quantum chemistry, nutrition and medicine), microscopic (medicine, nutrition, biology and microbiology), macroscopic (medicine such as surgery, nutrition, exercice) organizational (management, health policies)

This is not a wikipedia. This is my journal in understanding one of the oldest problem in human history: how to live longer?

If you want to contribute through ideas or work, contact me on the X account I made for the matter: @EtEntropy

PS: We currently live about 80 years in average, that is about 4200 weeks. Imagine now you have 4200 dollars and every week you pay 1 dollar. That is our reality as human animals.

Chapter 2: We are standing on the shoulders of Giants

The amount of information I have is infinitely small compared to that of human knowledge. My neurons are a biological machine that cannot store all humane knowledge. However, I can process as much information as possible in order to build better critical thinking about the tools I want to build.

This is where my journey starts. I want to accumulate as much information through books I will note here.

The first book that sparked interest for me is The chemistry book . This book not only brought back interest in science, but also gave me an understanding of Valence Bond Theory, Molecular Orbital Theory, Electron configuration.

This led me to read basic organic chemistry and the history of every atom in the periodic table Elementary: The Periodic Table Explained

I read after that The Physics Book where I finally learned about the Standard Model in physics where there are only 4 forces. I learned that gravitation is very low compared to electromagnetic forces. And that almost all things that you see are a result of electromagnetic forces such as chemistry, biology, medicine, when you touch an object, it is electromagnetic forces that make you not go through the object. The way a medicine acts upon bacteria is through electromagnetic forces that we interpret as biochemistry.

This left me with a sense of history but also as human people as biological machines. I understand now why most people are not 100% rational (even me). We are the slaves of our body, and yet we are our own body.

I need now to dive into quantum physics, in order to do this I had a long discussion with a quantum mathematics PHD with whom I had a long chat (Maybe one day I will publish our talk). To put it in a nutshell, since I want to have a rigorous knowledge in simulating matter but still want to use AI for matter simulation approximation, his advice was to read Functional Analysis by Michael Reed and Barry Simon.

This should enable me to understand the work done by Google deepmind.

Chapter 3: The world of simulations: Molecular dynamics

While I am studying quantum physics and mathematics every week. I still want to increase my knowledge about biology, medicine, and quantum chemistry.

First, when it comes to biology, I started smart biology course. It is a very visual learning course, and it does some simulation-like animations, which I doubt are real world simulation, but it helps a lot for learning. I doubted doing also a biomedical engineering degree, but I doubt it will help me achieve my goal. I am still hesitating about medecine, for which I will take the exam and see how it goes. I suspect it will help in understanding current rules in medicine, which will enable me to assess the precision of my simulation model.

If I achieve my goal of being a medical doctor I know already what my thesis will be: "Ab initio simulation of body growth, the role of AI." something like this

When it comes to the current state of this branch of computer science, I have made a whole page here with my thoughts on each program.

This is August 2024, I have worked on the exam to become a doctor for about a month. And the day before I passed the exam, I understood that this was not the right solution. Having studied for this medical exam was good, and actually worked well in tandem with Smart biology. However, I believe now I need to put the full force I have left after work to study simulation of quantum chemistry. In fact, in medicine you have to remember things by hearth, systems, illness, solutions. But these are general and use population statistics and can be misleading. Moreover, if I want to bring something new to the field, working to become a medical doctor is not a good idea as it is just using an old methodology. Computer simulations are promising, but these are not new. I need to understand what has been done already in the past and what is currently being done. As of now, Psi4 looks the most promising opensource simulation tool. I need to understand how it has been made in order to bring something to the table.